The effects of repetitive transcranial magnetic stimulation on body weight and food consumption in obese adults: A randomized controlled study

Kima, S.; Chungb, J.; Kimc, T.; Limd, S.; Kime, Y.; Euna, Y.; Leea, Y.

Abstract:

Background. although some studies have reported significant reductions in food cravings following the single-session of repetitive transcranial magnetic stimulation (rTMS), there is little research on the effects of multi-session of rTMS on food consumption and body weight in obese subjects. Objective: we conducted 4-week randomized, sham-controlled, single-blind, parallel-group trial to examine the effect of rTMS on body weight in obese adults. Methods: forty-three obese patients (body mass index [BMI] ≥25 kg/m2) aged between 18 and 70 years were randomized to the sham or real treatment group (21 in the TMS group and 22 in the sham treatment group). A total of 8 sessions of rTMS targeting the left dorsolateral prefrontal cortex (DLPFC) was provided over a period of 4 weeks. The primary outcome measure was weight change in kilograms from baseline to 4 weeks. Secondary endpoints included changes in anthropometric measures, cardiovascular risk factors, food intake, and appetite. Results: participants in the rTMS group showed significantly greater weight loss from baseline following the 8 session of rTMS (−2.75 ± 2.37 kg vs. 0.38 ± 1.0 kg, p < 0.01). Consistent with weight loss, there was a significant reduction in fat mass and visceral adipose tissue at week 4 in the rTMS group compared with the control group (p < 0.01). After the 8 sessions of rTMS, the TMS group consumed fewer total kilocalories and carbohydrates per day than the control group (p < 0.05). Conclusions: 8 sessions of HF rTMS delivered to the left DLPFC were effective in inducing weight loss and decreasing food intake in obese patients.

Patologie/Applicazioni:

• Stimolazione Magnetica Transcranica (TMS)

Anno:

2019

Tipo di pubblicazione:

Articolo

Parola chiave:

stimolazione magnetica transcranica; Obesità; parametri metabolici; DCA; disturbi del comportamento alimentare

Testata scientifica:

Brain stimulation

Mese:

11

Nota:

Questo studio presenta risultati molto positivi sull’uso della rTMS come trattamento non invasivo per l’obesità. I risultati mostrano una riduzione significativa di peso, massa grassa, senso di fame e desiderio di mangiare. Anche la sensibilità all’insulina è migliorata, evidenziando un effetto positivo sul metabolismo glucidico, mentre non sono emersi effetti negativi sull’umore o eventi avversi rilevanti. Complessivamente, lo studio dimostra che l’rTMS può rappresentare una promettente terapia complementare per la riduzione del peso corporeo e il miglioramento dei parametri metabolici.

DOI:

10.1016/j.brs.2019.07.020